Safety and Exploratory Efficacy Study of SF0166 in the Treatment of Neovascular Age-Related Macular Degeneration (AMD)

Inclusion Criteria: 1. Male or female, 50 years of age or older. 2. Active subfoveal choroidal neovascularization due to Age-related Macular Degeneration (AMD) in the study eye that meet the following criteria: * Total lesion ≤12 Macular Photocoagulation Study (MPS) disc areas * Choroidal neovascularization (CNV) \>50% of lesion area * Intraretinal or subretinal fluid due to choroidal neovascularization (CNV) visible on optical coherence tomography (OCT) * No atrophy or fibrosis involving the center of the fovea 3. Best-corrected Visual Acuity (BCVA) between 78 and 25 letters, inclusive, in the study eye at the screening/randomization visit using Early Treatment Diabetic Retinopathy Study (ETDRS) testing, with BCVA decrement primarily attributable to neovascular Age-related Macular Degeneration (AMD). 4. Treatment naïve (i.e., no previous anti--vascular endothelial growth factor \[VEGF\] treatment in the study eye) or previously treated study eye with adequate washout defined below: 1. Lucentis (ranibizumab): 30-day washout 2. Avastin (bevacizumab): 30-day washout 3. Eylea (aflibercept): 60-day washout 4. Macugen (pegaptanib): 45-day washout 5. Willing and able to return for all study visits. 6. Able to adhere to the study dosing requirements. 7. Understands and signs the written informed consent form. Exclusion Criteria: 1. Non-study eye best corrected visual acuity (BCVA) worse than 20 letters at the screening/randomization visit using Early Treatment Diabetic Retinopathy Study (ETDRS) testing. 2. Choroidal neovascularization (CNV) in the study eye secondary to other causes (e.g., pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, choroidal rupture, posterior uveitis, or multifocal choroiditis). 3. Previous macular laser photocoagulation or ocular photodynamic therapy in the study eye. 4. Media opacities or abnormalities in the study eye that would preclude visualization of the retina. 5. Other retinal pathologies in the study eye that would interfere with vision. 6. Retinal pigment epithelial (RPE) tear in the study eye. 7. Significant epiretinal membrane, posterior hyaloidal traction, and/or vitreomacular traction in the study eye as determined by optical coherence tomography (OCT) results. 8. Uncontrolled glaucoma or ocular hypertension in the study eye defined as an Intraocular Pressure (IOP) \>25 millimeter of mercury (mmHg) regardless of concomitant treatment with IOP lowering medications. 9. Uncontrolled hypertension defined as systolic \>180 mmHg or \>160 mmHg on 2 consecutive measurements (during the same visit) or diastolic \>100 mmHg on optimal medical regimen 10. Previous pars plana vitrectomy in the study eye. 11. Any intraocular surgery in the study eye within 90 days (3 months) prior to study enrollment. 12. Yttrium aluminium garnet (YAG) laser treatment in the study eye within 30 days (1 month) prior to study enrollment. 13. Intravitreal/periocular/topical ocular steroids of any type in the study eye within 90 days (3 months) prior to study enrollment. 14. Concomitant use any topical ophthalmic medications in the study eye, including dry eye or glaucoma medications, unless on a stable dose for at least 90 days (3 months) prior to study enrollment and expected to stay on stable dose throughout study participation. Artificial tears are allowed. 15. Chronic or recurrent uveitis in the study eye. 16. Ongoing ocular infection or inflammation in either eye. 17. A history of cataract surgery complicated by vitreous loss in the study eye. 18. Congenital eye malformations in the study eye. 19. A history of penetrating ocular trauma in the study eye. 20. Mentally handicapped. 21. Females of childbearing potential (i.e., who are not postmenopausal for at least 1 year or surgically sterile for at least 6 weeks prior to Visit 1 - Screening/Randomization) who are lactating, or who are pregnant as determined by a positive urine pregnancy test (UPT) at Visit 1 - Screening/Randomization. Women of childbearing potential must agree to use acceptable methods of birth control throughout the study. Acceptable methods of birth control include tubal ligation, transdermal patch, intrauterine devices/systems, oral/implantable/injectable or contraceptives, sexual abstinence, double barrier method, or vasectomized partner. 22. Participation in any other investigational device or drug clinical research study within 30 days of Visit 1 - Screening/Randomization. 23. Contraindication to the study medications or fluorescein dye. 24. Other ocular pathologies that in the Investigator's opinion would interfere with vision in the study eye.