HMGB1 in ICU-survivors

Karolinska University Hospital100 enrolled

Overview

Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sepsis Cognitive Impairment

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male/Female age 18-17 * Expected ICU-stay more than 24 hours Exclusion Criteria: * Dont understand the language * Substance abuse, alcohol or drugs * Blind, deaf or suffering from aphasia * Ongoing psychiatric illness or psychopharmacological treatment * Suffering from dementia och mentally impaired * Structured brain damage or meningitis * Palliative Care * ICU-treated for more than 48 hours * Transferred from other ICU * Being treated with ECMO * Not having residency in Stockholm

Locations (1)

Dept of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital

Stockholm, Sweden

Outcomes

Primary Outcomes

Is HMGB1 elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice?

Time frame: 2 years

Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?

Time frame: 4 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.