In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked. The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters. The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts. After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).
242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters) First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
167
All the participant will performed the same evaluation and blood analysis: * A clinical assessment by psychiatrics assessing psychiatric disorder and suicidal behavior * Thermal stimulation for pain assessment * Computer game named Cyberball: test of social exclusion * Self report questionnaire for the assessment of reject sensitivity, relationship style, impulsivity, childhood trauma. * Routine blood sampling
Montpellier Hospital University
Montpellier, France
Pain tolerance reported by the patient
temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
Time frame: During thermal stimulation
Pain intensity reported by the patient
comparison between the three groups of the pain intensity (assessed by likert scale) at constant temperature (43 ° C)
Time frame: During thermal stimulation
Pain threshold reported by the patient
comparison between the three groups of the pain threshold (temperature perceived as painful)
Time frame: During thermal stimulation
Temperature assessed at 4/10 on likert scale
comparison between the three groups of the temperature assessed at 4/10 on a visual analogic painful scale, kinetics of pain intensity by visual analog scale (VAS) scale.
Time frame: During thermal stimulation performed at the inclusion
Kinetics of pain intensity
comparison between the three groups of kinetics of pain intensity by visual analog scale (VAS) scale.
Time frame: During thermal stimulation performed at the inclusion
Social distress perception assessed by social distress questionnaire
comparison between the three groups of the score of social distress scale after cyberball game
Time frame: At V2 (one week maximum after the inclusion)
Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)
comparison between the three groups of the score of social distress scale after cyberball game
Time frame: At the inclusion
Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)
comparison between the three groups of the score of social rejection sensitivity by RSQ
Time frame: At the inclusion
Psychological pain intensity
comparison between the three groups of the score of psychological pain intensity assessed by VAS scale.
Time frame: At V2 (one week maximum after the inclusion)
Measure of cardiac frequency in response to thermal pain
comparison between the three groups of the cardiac frequency.
Time frame: At V2 (one week maximum after the inclusion)
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