Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality

Seoul National University Hospital1,099 enrolled

Overview

Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Acute kidney injury (AKI) after cardiovascular surgery remains a serious complication associated with increased mortality for up to 10 years. The incidence of AKI after cardiovascular surgery is as high as 55% and the incidence of renal replacement therapy (RRT) to be up to 8 %. Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Study Type

OBSERVATIONAL

Enrollment

1,099

Conditions

Acute Kidney Injury

Interventions

Cardiovascular surgery with cardiopulmonary bypassPROCEDURE

Patients who underwent cardiovascular surgery including valve replacement or thoracic aortic surgery with cardiopulmonary bypass

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients who underwent cardiovascular surgeries with cardiopulmonary bypass (CPB), including valve replacement and surgery on the thoracic aorta at the Seoul National University Hospital between 2007 and 2015 Exclusion Criteria: * Missing preoperative serum creatinine (sCr) values * Missing preoperative platelet, neutrophil and lymphocyte counts * Patients who underwent preoperative hemodialysis

Locations (1)

Seoul National University Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Acute kidney injury

acute kidney injury during postoperative seven days defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria

Time frame: postoperative day seven

Secondary Outcomes

All-cause mortality

all-cause mortality after cardiovascular surgery after postoperative seven years

Time frame: postoperative seven years

Data from ClinicalTrials.gov

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