Triggering of Follicular Maturation

Assiut University160 enrolled

Overview

The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes. This results in the secretion of follicle stimulating hormone and luteinizing hormone in hourly pulses that regulate follicular growth. At midcycle, rapidly rising estradiol from the dominant follicle and a small rise in progesterone lead to a gonadotrophic surge. An increase in the amplitude of Luteinizing hormone and Follicle stimulating hormone pulses initiates oocyte maturity and triggers ovulation approximately

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

160

Conditions

Increase Pregnancy Rate

Interventions

Recombinant Human Chorionic GonadotrophinDRUG

250 unit intramuscular

human chorionic gonadotrophin + gonadotrophin releasing hormone agonistDRUG

250 unit intramuscular + 1 mg subcutaneous

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Infertile couples wishing to do intracytoplasmic injection trial . 2. first intracytoplasmic injection trial 3. Body mass index:18-30. 5-Antral follicular count: more than 5 follicles in one ovary 6-normal, mild or moderate male factor infertility. 7- Antimullerian hormone \>1 ng/ml Exclusion Criteria: 1. Azoospermic male. 2. Body mass index more than 29. 3. Patients with endometriosis . 4. Antimullerian hormone \< 1 ng/ml

Locations (1)

Ahmed Abbas

Assiut, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

Number of M II oocytes in both groups

Time frame: 24 hours

Secondary Outcomes

Fertilization rate in each group

Time frame: 3 days

Clinical pregnancy rate in each group

Time frame: 15 days

Data from ClinicalTrials.gov

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