The purpose of this study is to examine the effect of different vegetables on cardiovascular function in subjects with moderately increased blood pressure. Specifically we are comparing the effects of vegetables with a high natural content of inorganic nitrate with those of vegetables with a low nitrate content.
Recent studies indicate that dietary-derived inorganic nitrate can affect blood pressure in humans by converting into nitric oxide bioactivity. Here we will study if vegetables that naturally contain high amounts of nitrate (green leafy vegetables) can lower blood pressure and whether any effect is attributed to the nitrate anion. High nitrate vegetables are compared with vegetables low in nitrate (e.g. tomatoes, sweet pepper). After a 2 week run in period where all subjects receive vegetables low in nitrate, the participants are randomized to one of three interventions. One third of the patients receive high-nitrate vegetables + a placebo pill (KCl), one third receives low-nitrate vegetables + placebo and the third group receives low-nitrate vegetables + a nitrate pill (KNO3). The nitrate content in the pill is precisely matched to the nitrate content in the high-nitrate vegetable group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
225
vegetables naturally high in nitrate
pill containing KNO3
vegetables naturally low in nitrate
Karolinska Institutet
Stockholm, Sweden
Difference in Change in ambulatory Systolic Blood Pressure From Baseline
Measure how 24h ambulatory SBP changes over 5 weeks with the different interventions
Time frame: 5 weeks intervention
Difference in Change in ambulatory diastolic Blood Pressure From Baseline
Measure how 24h ambulatory DBP changes over 5 weeks with the different interventions
Time frame: 5 weeks intervention
Difference in Change in office diastolic blood pressure (DBP)
BP is measured during a hospital visit every week during intervention
Time frame: Once every week for 5 weeks
Difference in Change in flow mediated dilatation (FMD)
FMD is measured before and after the interventions
Time frame: 5 weeks intervention
Difference in Change in office Systolic Blood Pressure From Baseline
Measure how clinic SBP changes weekly over 5 weeks with the different interventions
Time frame: 5 weeks intervention
Difference in Change in Daytime Ambulatory systolic Blood Pressure From Baseline
Measure how 24h ambulatory daytime SBP changes over 5 weeks with the different interventions
Time frame: 5 weeks intervention
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