How Orally Consumed 3-hydroxybuturate Alters Metabolism

University of Aarhus6 enrolled

Overview

This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.

Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken. Placebo: subjects drink saline. Same sampling as on intervention day.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Acute Ketosis

Interventions

3-hydroxybuturateOTHER

Drink of ketone bodies

PlaceboOTHER

Drink of saline

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI 20-30 Exclusion Criteria: * Smoking * alcohol or drug abuse * Critically ill

Locations (1)

Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

3-hydroxybuturate

blood level of 3-hydroxybuturate

Time frame: 0-270 minutes

Secondary Outcomes

Glucose

Glucose tracer kinetics, endogenous glucose production, muscle biopsy

Time frame: 0-270 minutes

lipid metabolism

Palmitate tracer kinetics, free fatty acid accumulation, adipose tissue biopsies

Time frame: 0-270 minutes

Data from ClinicalTrials.gov

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