EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

Rennes University Hospital44 enrolled

Overview

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation. The exhibition is evaluated by population pharmacokinetic modeling.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Infection

Interventions

blood sampleOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age over 18 years * Hospitalisation in intensive care * Treatment with ECMO or without ECMO * Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours * With an arterial catheter * Patient Information or their next of kin according to the patients status. Exclusion Criteria: * Pregnancy * Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty

Locations (1)

CHU Rennes

Rennes, France

Outcomes

Primary Outcomes

Measure exposure to piperacillin

evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat

Time frame: Day 1

Data from ClinicalTrials.gov

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