Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension

Inclusion Criteria: * average office systolic BP of 150 mmHg or greater or office diastolic BP of 90 mmHg or greater (both in the sitting position) * 24-hr ambulatory BP 140 mmHg or greater. Exclusion Criteria: * Secondary hypertension (sleep apnoea can be included.) * Type I diabetes or uncontrolled Type II diabetes with HbA1c 8.4% or greater * Known or concurrent chronic active inflammatory bowel diseases (e.g. Crohn's disease, ulcerative colitis etc.) * eGFR\<40 mL/min/1.73m2 (per predictive equation Japanese Society of Nephrology) * Known severe cardiovascular events within 3 months or severe cerebrovascular events * Patients those who are planned to receive PCI or other operation for iscaemic cardiovascular disease within 8 months * Concurrent persistent atrial fibrillation * Patients those who are on active implantable medical devices * Primary pulmonary hypertension * Patients those who are contraindicated to, or confirmed to have intolerable anaphylactic reaction or uncontrollable allergy to contrast media