This clinical trial studies how well delayed fludeoxyglucose F-18 (18F-FDG) positron emission tomography (PET)/computed tomography (CT) works in improving visualization of brain tumors in patients with glioblastoma. Radiotracers such as 18F-FDG are highly taken up by tumors in the brain and are visualized using PET/CT. Increasing the interval of time between 18F-FDG administration and PET/CT scan may improve the visualization of brain tumors in patients with glioblastoma.
PRIMARY OBJECTIVES: I. To improve the visualization/delineation of glioblastoma lesions using delayed 18F-FDG PET/CT imaging. OUTLINE: Patients receive fludeoxyglucose F-18 intravenously (IV). Patients then undergo a standard of care PET/CT scan at 60 minutes and a second PET/CT scan at 240 minutes after injection. Note: Standard Uptake Value (SUV) is defined for state-of-the art PET/CT scanners as Standardized uptake values = count activity per ml within region of interest (MBq/ml)/\[injected dose (MBq)/body weight (kgx1000)\]
Study Type
OBSERVATIONAL
Undergo 18F-FDG PET/CT
Given IV
Undergo 18F-FDG PET/CT
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States
Tumor-to-background ratio on delayed scans (240 min after injection)
Ratio between Standardized uptake values (tumor region) and Standardized uptake values (physiological uptake of brain tissue)
Time frame: Baseline up to 240 minutes after injection
Tumor-to-background ratio on standard scans (60 min after injection)
Ratio between Standardized uptake values (tumor region) and Standardized uptake values (physiological uptake of brain tissue)
Time frame: Baseline up to 60 minutes after injection
Standard uptake value comparison
Comparison of Standardized uptake values (tumor region) to visual and quantitative parameters on delayed scans (240 min after injection)
Time frame: 240 minutes post injection
Standard uptake value comparison
Comparison of Standardized uptake values (tumor region) to visual and quantitative parameters on standard scans (60 min after injection)
Time frame: 60 minutes post injection
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