A Single-dose, Dose-escalation Study of a Long-acting MOD-5014 in Healthy Adult Male

Inclusion Criteria: 1. Men, 18-50 years of age, inclusive, at the screening visit. 2. Subjects must provide written informed consent prior to participating in the study. 3. Considered healthy based on medical history, physical examination and clinical laboratory results. 4. Body Mass Index (BMI) 19.0-30.0 kg/m2 and total body weight \>50 Kg. 5. Fertile men must agree to use a barrier contraceptive (condom) for 30 days post-dosing and are restricted from donating sperm for 30 days after dosing. Subjects with a vasectomy performed more than 6 months prior to treatment are also acceptable. 6. Supine blood pressure and heart rate within normal limits (systolic 90-140 mmHg; diastolic 50-90 mmHg, heart rate 45-100 beats per minute). No evidence of orthostatic hypotension. 7. Triglyceride ≤ 200 mg/dl 8. ECG with no clinically significant abnormalities recorded at Screening visit and on dosing day (before drug administration): PR interval within 120 and 210 ms, QRS interval \< 120 ms, and QTc interval 450 ms. 9. Negative human immunodeficiency virus (HIV), hepatitis B or hepatitis C serology tests at screening. 10. Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. 11. Non-smoking and no use of any tobacco or nicotine product by declaration for a period for at least 6 month prior to screening period. Exclusion Criteria: 1. Family history of blood clots. 2. Have had, within one month prior to study drug administration, a major surgical procedure (e.g. orthopedic, abdominal) or have an elective surgery planned within the study period. 3. Any history of arterial and/or venous thromboembolic events (such as myocardial infarction, ischemic strokes, transient ischemic attacks, deep venous thrombosis or pulmonary embolism). 4. History or current drug/alcohol abuse (excluding use of medicinal cannabis for pain management). History of regular alcohol consumption exceeding - 14 drinks/week for men (1 drink = 5 ounces \[150 mL\] of wine or 12 ounces \[360 mL\] of beer or 1.5 ounces \[45 mL\] of hard liquor) within 6 months of screening. Positive urine drug of abuse (DoA) in screening and on admission. Positive breath alcohol test on admission. 5. Known allergy to any drug. Known allergy or hypersensitivity to any of the test compounds or materials or contraindication to test product. 6. Use of any prescription or over-the-counter (OTC) medications, including vitamins and herbal or dietary supplements within 14 days prior to dosing. Paracetamol for symptomatic relief of pain is allowed until 24 hours prior to the study drug administration. 7. Subjects who have received any vaccines within 4 weeks prior to study drug administration. 8. Participation in another clinical trial within 30 days.