Observational Study of Angiographic Coregistered Optical Coherence Tomography in Patients Undergoing PCI

Inclusion Criteria: * Age ≥ 18 years. * Patient provides signed written informed consent before any study-specific procedure. * Patients suffer from coronary artery disease (CAD) including at least one angiographically significant (\>70% visual estimation) stenosis present in a native coronary artery with planned PCI. Exclusion Criteria: * Subjects with emergent PCI or in cardiogenic shock. * Subjects with target left main (LM) lesion, with restenosis or stent thrombosis in the target vessel or with aorto-ostial lesion location within 3 mm of the aorta junction (both right and left). * Extreme angulation (\> 90°) or excessive tortuosity (\> two 45° angles) proximal to or within the target lesion. * Known renal insufficiency (examples being but not limited to estimated glomerular Filtration rate (eGFR) \< 50 ml/kg/m2, serum creatinine ≥ 2.5 mg/dL or on dialysis). * Any other medical condition that in the opinion of the investigator will interfere with patients safety or study results. * Currently participating in another clinical study that interferes with study results. * Pregnant or nursing subjects and those who plan pregnancy in the period up to 1 year following index procedure. * Any condition that precludes the subject from undergoing PCI, for example subjects with heparin induced thrombocytopenia, or contrast allergy