This trial is conducted in Europe. The aim of this trial is to investigate the influence of oral semaglutide on the pharmacokinetics (the exposure of the trial drug in the body) of levothyroxine and the influence of co-administered tablets on the pharmacokinetics of semaglutide administered orally in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
45
Oral administration once daily alone or together with levothyroxine or Placebo
Oral administration once daily alone or together with levothyroxine or semaglutide
Oral administration alone or together with SNAC or oral semaglutide
Oral administration once daily together with semaglutide
Novo Nordisk Investigational Site
Berlin, Germany
Baseline-corrected area under the total T4 serum concentration-time curve from 0 to 48 hours after a single dose of levothyroxine
Time frame: On day 1 (levothyroxine administered alone), on day 38 (levothyroxine co-administered with SNAC) and on day 89 (levothyroxine co-administered with oral semaglutide)
Area under the semaglutide plasma concentration-time curve during a dosing interval (0-24 hours) at steady state
Time frame: On day 88 (oral semaglutide administered alone) and on day 139 (oral semaglutide co-administered with placebo tablets)
Baseline-corrected maximum observed total T4 serum concentration from 0 to 48 hours after a single dose of levothyroxine
Time frame: On day 1 (levothyroxine administered alone), on day 38 (levothyroxine co-administered with SNAC) and on day 89 (levothyroxine co-administered with oral semaglutide)
Maximum observed semaglutide plasma concentration during a dosing interval from (0-24 hours) at steady state
Time frame: On day 88 (oral semaglutide administered alone) and on day 139 (oral semaglutide co-administered with placebo tablets)
Area under the SNAC plasma concentration-time curve during a dosing interval (0-24 hours) at steady state
Time frame: On day 88 (oral semaglutide administered alone) and on day 139 (oral semaglutide co-administered with placebo tablets)
Maximum observed SNAC plasma concentration during a dosing interval (0-24 hours) at steady state
Time frame: On day 88 (oral semaglutide administered alone) and on day 139 (oral semaglutide co-administered with placebo tablets)
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