Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney Transplant Recipients

Inclusion Criteria: * Subject is a recipient of a de novo kidney from a living or deceased donor and has biopsy-proven, primary FSGS (pFSGS) as a cause of end stage renal disease (ESRD) in the subject's native kidneys (initial diagnosing biopsy report is required). A subject who has biopsy-proven pFSGS as a cause of ESRD, and the subject's most current graft failure(s) is due to the recurrence of FSGS, is eligible. * Subject is anticipated to receive first oral dose of tacrolimus within 48 hours of transplant procedure. * Subject must be willing and able to comply with the study requirements including prohibited concomitant medication restrictions. * Subject agrees not to participate in another interventional study while on treatment. Exclusion Criteria: * Subject has Induction therapy, other than study-assigned basiliximab, planned as part of initial immunosuppressive regimen. * Subject has a diagnosis of secondary FSGS (familial, virus associated, medication, etc.) or a defined genetic cause of FSGS. * Subject has previously received any organ transplant including a kidney and the most current graft failure(s) is not due to the recurrence of FSGS. * Subject will receive a kidney as part of a multi-organ transplant. * Subject will receive a dual kidney transplant from a deceased donor. * Subject will receive a kidney with an anticipated cold ischemia time (CIT) of \> 30 hours. * Subject will receive a kidney that meets BOTH Extended Criteria Donor (ECD) and Donation after Cardiac Death (DCD) criteria. (A kidney that meets either ECD OR DCD criteria may be eligible for inclusion.) * Subject will receive a blood group system (A, AB, B, O, ABO) incompatible (including A2 into B or O) donor kidney. * Recipient or donor is known to be seropositive for human immuno-deficiency virus (HIV). * Subject has a current calculated panel reactive antibody (cPRA) level \> 50%. * Subject has a current malignancy or a history of malignancy (within the past 5 years), except nonmetastatic basal or squamous cell carcinoma of the skin that has been treated successfully, or a renal cell carcinoma that has been treated successfully more than 2 years prior to transplantation. * Subject has significant liver disease, defined as having during the past 21 days consistently elevated aspartate aminotransferase (AST) (SGOT) and/or alanine aminotransferase (ALT) (SGPT) levels greater than 1.5 times the upper value of the normal range of the investigational site. * Subject is known to have a positive test for latent tuberculosis (TB) and has not previously received adequate anti-microbial therapy/or would require TB prophylaxis after transplant. * Subject has an uncontrolled concomitant infection or any other unstable medical condition that could interfere with the study objectives. * Subject is concurrently participating in another drug study or has received an investigational drug up to 30 days or 5 half-lives prior to transplant. * Subject is currently receiving or has received up to 8 weeks prior to transplant an immunologic biologic compound (i.e., tumor necrosis factor (TNF) inhibitors, \[e.g., etanercept, adalimumab\], intravenous immunoglobulin (IVIG)). A subject who has previously received a kidney organ transplant and is currently on an immunosuppression regimen that includes MMF, or any of its components, must discontinue MMF. * Subject has previously received bleselumab or participated in a clinical study with bleselumab. * Subject has a known hypersensitivity to tacrolimus, MMF, basiliximab, corticosteroids, or any of the components. * Subject has any form of substance abuse, psychiatric disorder, or a condition that could invalidate communication with the Investigator. * Subject has a clinically significant abnormal electrocardiogram (ECG) at Screening. * Subject is unlikely to comply with the visits scheduled in the protocol