The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
To compare the effect of each herb extracts to protect the skin from the adverse effects of radiation therapy in patients with breast cancer with herbal extract products.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
150
Apply moisture cream to the treatment skin everyday after radiation therapy
Apply cucumber cream to the treatment skin everyday after radiation therapy
Apply centella cream to the treatment skin everyday after radiation therapy
ChulaBhorn Hospital
Bangkok, Thailand
Change of dermatitis grading
RTOG (Radiation Therapy Oncology Group) Cooperative Group Common Toxicity Criteria Skin Grade 0:None or no change Grade 1:Scattered macular or papular eruption or erythema that is asymptomatic Grade 2:Scattered macular or papular eruption or erythema with pruritis or other associated symptoms Grade 3:Generalized symptomatic macular, papular, or vesicular eruption Grade 4:Exfoliative dermatitis or ulcerating dermatitis Grade 5:If that toxicity caused the death of the patient.
Time frame: Change from baseline dermatitis grading at 1, 2, 3, 4, 5 weeks and at 9 week.
Patient satisfaction with the cream
Scoring 1-4 1. not satisfied 2. slightly satisfied 3. moderately satisfied 4. very satisfied
Time frame: At 9 week from date of randomization
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Apply thunbergia cream to the treatment skin everyday after radiation therapy