For acute severe colitis (ASC) patients, corticosteroids (CS) was recommended as the first-line treatment in the guideline, but patients have a great risk of requiring colectomy or turning to second-line treatment. This study aim to verify the effectiveness of ulcerative colitis endoscopic index of severity(UCEIS) in predicting the reaction to corticosteroids, and explores the possibility that noninvasive marker fecal calprotectin (FC) could act as an alternative to UCEIS.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
117
Intravenous steroids were started with methylprednisolone 60 mg/d or hydrocortisone 400 mg/d for 3 days.
Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University
Nanjing, Jiangsu, China
stool frequency at day 3
The response to intravenous steroid therapy was judged at day 3 according to Oxford criteria.
Time frame: 3 days
C-reactive protein (CRP) at day 3
The response to intravenous steroid therapy was judged at day 3 according to Oxford criteria.
Time frame: 3 days
ulcerative colitis endoscopic index of severity (UCEIS) before treatment
The UCEIS consists of the following three descriptors and was calculated as a simple sum: vascular pattern (scored 0-2), bleeding (scored 0-3), erosions and ulcers (scored 0-3).
Time frame: 3 days
Fecal Calprotectin before treatment
FC was measured strictly with the instruction of the commercial test kits.
Time frame: 3 days
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