The aim of the study is to investigate a pre and post workout supplementation (15 days) with Recoverben® , a Aloysia citriodora extract on recovery after exhaustive exercise. Effects will be investigated with 400mg Recoverben® and compared to placebo.
The aim of the study is to investigate a pre and post workout supplementation (15 days) with Recoverben® , a Aloysia citriodora extract on recovery after exhaustive exercise. Effects will be investigated with 400mg Recoverben® and compared to placebo. Targeted parameter will be determined at the beginning of the study and after supplementation, each. Parameter include maximal strength (MVC), muscle soreness (VAS), pain sensitivity (Algometry) and biomarkers (CK, IL-6, glutathione peroxidase).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
40
2 capsules with 200mg - daily dosage 400mg
2 capsules with 200mg - daily dosage 400mg
Biotesys GmbH
Esslingen am Neckar, Germany
Change of muscle soreness (VAS) over time
In the current study, pain following eccentric exercise will be assessed by using a 100 mm visual analogue scale after the subjects performing a standardized movement.
Time frame: Chance over time after 10 days of supplementation (pre stress test and 3h, 24h, 48 h, 96h after stress test)
Monitoring of related adverse events
Reporting of adverse effects to evaluate tolerability
Time frame: During study execution over 15 days
Change of maximal concentric strength/ maximal voluntary contraction (MVC) over time
Maximal concentric strength of the M. Quadriceps femoris will be assessed by measuring maximal isometric concentric strength using a dynamometer
Time frame: Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test)
Change of pressure pain (Algometry) over time
The threshold for pressure induced pain will be measured using an algometer.
Time frame: Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test)
Change of retrospective pain (Likert scale) over time
Evaluation of the perceived pain retrospectively by using the Likert scale for muscle soreness
Time frame: Chance over time after 10 days of supplementation (pre stress test and 24h, 48h, 96h after stress test)
Change of creatine kinase over time
Time frame: Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test)
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Change of of glutathione peroxidase over time
Time frame: Chance over time after 10 days of supplementation (pre stress test and 24h and 48 h after stress test)
Change of interleukin-6 over time
Time frame: Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test)