Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy

Centre Hospitalier Universitaire de Nīmes300 enrolled

Overview

The main objective of this study is to establish an optimal threshold Early parathormon (PTH) assay in order to exclude hypoparathyroidism , that is to say to obtain a negative predictive value of hypoparathyroidism highest possible.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Hypoparathyroidism

Interventions

immediate post operative bioassay of Parathyroid HormoneBIOLOGICAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients consecutively operated on between February 1, 2012 and December 1, 2013 * Total thyroidectomy +/- lymphadenectomy * Respect of clinicobiological protocol presented above * The ( the ) patient ( e) was informed ( e) on the implementation of the study 's objectives, constraints and patient rights * The ( the ) patient ( e) is under ( e) at least 18 years Exclusion Criteria: * The ( the ) patient ( e) is under guardianship, curatorship or under guard saves justice * It is not possible to give to ( the ) patient ( e) informed information * History of cervical radiotherapy * Previous history of dysfunction of the parathyroid glands * Previous history of surgery of the parathyroid glands * A history of kidney failure or hepatocellular * History of osteomalacia or Paget's disease * unhealed cancer antecedent * History of sarcoidosis

Outcomes

Primary Outcomes

the presence/absence of hypoparathyroidism

hypoparathyroidism is defined as: corrected serum calcium Day 1 \<1.90 and / or symptoms of hypocalcemia (cramps, tingling of the extremities and peri-oral) to Day 1 authenticated by a VAS score\> 3.

Time frame: day 1

Data from ClinicalTrials.gov

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