Beta2-mimetics such as Salbutamol have been shown to have ergogenic effects. Acute and chronic inhaled or oral doses of Salbutamol have been shown to increase whole body exercise and muscle performances. The underlying mechanisms are however unclear. Some data suggest that Salbutamol may have some effects on the central nervous system which may explain the improved exercise and neuromuscular performances. The present study aims to assess the effects of acite inhaled or oral Salbutamol intake on the neuromuscular system by using neurostimulation techniques and magnetic resonance imaging.
The effects of Salbutamol intake will be assessed by using transcranial magnetic stimulation on one hand and magnetic resonance imaging on the other hand. Maximal voluntary activation and cerebral activation will be measured during motor tasks performed until exhaustion after acute inhaled slabutamol intake, acture oral salbutamol intake or oral placebo intake.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
15
Acute intake of Albuterol, a beta2-mimetic, either inhaled or oral.
Acute oral intake of a placebo drug
Grenoble University Hospital
Grenoble, France
Maximal voluntary activation
Measurement performed by using transcranial magnetic stimulation, superimposed on submaximal and maximal quadricep contractions
Time frame: Measured immediatly after treatment intake (within 1 h)
Cortical activation
Measurement performed by using magnetic resonance imaging and the intensity of the BOLD signal in response to a motor task.
Time frame: Measured immediatly after treatment intake (within 1 h)
Exercise endurance
Time to exhaustion during the exercise muscle test.
Time frame: Measured immediatly after treatment intake (within 1 h)
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