Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement

Inclusion Criteria: * Primary unilateral TKA indicated for MUA (knee flexion angle less than 90°) * Primary Diagnosis of OA for TKA * MUA indicated within 5 to 12 weeks of primary surgery * Age greater than or equal to 18 years * Patients with less than 10 degrees of a flexion contracture Exclusion Criteria: * Patients who are wheelchair bound * Patients requiring concomitant arthroscopic or open procedures * Revision TKA * Patients requiring bilateral MUA * Patients with renal disease (Creatinine \> 1.5, and/or estimated creatinine clearance less than 30 mL/min) * Patients with hepatic disease (known liver disease, cirrhosis, and/or AST/ALT\>60) * Patients concurrently taking strong CYP3A4 inhibitors: * Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, verapamil * Patients concurrently taking strong P-glycoprotein inhibitors: * Cyclosporine, ranolazine * Patients concurrently taking medications that increase the risk for myopathy and rhabdomyolysis: * atorvastatin, fluvastatin, pravastatin, simvastatin, fibrates, gemfibrozil, digoxin * Patients with a history of blood dyscrasias * Pregnant patients * Patients who are nursing mothers * Patients with reported allergy to colchicine * Non-English speaking patients