Subcutaneous Median Nerve Neuromodulation For Drug-Treatment Resistant Hypertension.

Inclusion Criteria: * Individual is ≥30 and \<75 years of age at the time of randomization. * Individual is receiving a stable medication regimen including maximally tolerated doses of 3 or more anti-hypertensive medications of different classes, of which one must be a diuretic (with no changes for a minimum of 4 weeks prior to screening) that is expected to be maintained without changes for at least 6 months post randomization. * Individual has an office systolic BP ≥140 mmHg and ≤180 mmHg and diastolic BP ≥80 mmHg and ≤110 mmHg measured at an initial screening visit and a confirmatory baseline visit. * Individual has a 24 hour ambulatory systolic BP of ≥135 mmHg and ≤175 mmHg at baseline. Exclusion Criteria: * Individual in whom medications are expected to change in the next 9 months (6 months post randomization). * Individual does not agree to have all study procedures performed, and is not competent and willing to provide written, informed consent to participate in this clinical study. * Individual has type 1 diabetes mellitus or type 2 diabetes mellitus with an A1C ≥ 9%. * Individual has experienced, within one year of the screening visit, a myocardial infarction, hospitalized unstable angina pectoris, hospitalized heart failure, TIA or a cerebrovascular accident. * Individual has a scheduled or planned surgery, cardiovascular intervention, or dialysis in the next six months. * Individual has hemodynamically significant valvular heart disease for which reduction of BP would be considered hazardous. * Individual has any serious medical condition with a prognosis of \<2 years. * Individual has significant anemia (hemoglobin \<100g/L), thrombocytopenia (platelets \<100x10(9) /L) or a severe bleeding disorder eg. hemophilia. * Individual has known secondary hypertension including primary aldosteronism (other than associated with obstructive sleep apnea). * Individual has pulmonary hypertension. * Individual requires chronic oxygen support or mechanical ventilation (e.g., tracheostomy, CPAP, BiPAP) other than nocturnal respiratory support for sleep apnea. * Individual is pregnant, nursing or planning to become pregnant. * Individual has known or suspected history of medication non-compliance. * Individual has known unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply with study follow-up requirements. * Individual has undergone renal denervation or baroreflex activation therapy. * Individual has an estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m2. * Individual has another implantable stimulation device including a cardiac pacemaker, ICD, spinal cord stimulator, brain stimulator, vagus nerve stimulator, peripheral nerve stimulator, or cochlear implant. * Individual is scheduled to have an MRI. * Individual is currently enrolled in another investigational drug or device trial that has not reached its primary endpoint. * Individual is working nights or is on a rotating work schedule. * Individual has an arm circumference too large or small to allow accurate blood pressure measurement with available devices. * Individual has a history of carpal tunnel syndrome/wrist surgery or other pre-existing compression or non-compression neuropathy in the forearm, wrist or hands that is incompatible with device placement.