Assess impact of potato phytochemical on post-prandial gastric emptying and glucose release from products in a pilot human study.
Preclinical data obtained using an Caco-2 intestinal cell model and enzyme assays suggest phenolic-rich potato extracts decrease intestinal glucose transport. The aim is to determine if these effects extend to the the an in vivo situation. Specifically, the glycemic response following consumption of phenolic rich pigmented potatoes compared to white potatoes with lower phenolic content will be measured. Gastric emptying will also be measured to show the effects are in fact due to rate of carbohydrate digestion and intestinal glucose transport and not gastric emptying rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
11
Blood Glucose
blood taken at 10, 20, 30, 60, and 120 minutes by finger prick
Time frame: up to 2 hours
Gastric emptying
Breath Hydrogen concentrations will be measured every 15 minutes for 4 hours
Time frame: up to 4 hours
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