Motivational Interviewing to Support LDL-C Therapeutic Goals and Lipid-Lowering Therapy Compliance in Patients With Acute Coronary Syndromes: a Prospective Randomized Clinical Study

AHEPA University Hospital360 enrolled

Overview

This study will investigate the impact of motivational interviewing in achieving low-density lipoprotein cholesterol therapeutic targets in patients with acute coronary syndromes.

To determine whether a strategy of enhanced information about the risks of high plasma low-density lipoprotein cholesterol (LDL-C) and the importance of lipid-lowering medication together with close follow-up and motivational interviewing is superior than usual care in achieving LDL-C therapeutic targets, as set by current practice guidelines (LDL-C \<70 mg/dL or \>50% reduction from baseline LDL-C) in patients with acute coronary syndromes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

360

Conditions

Acute Coronary Syndrome

Interventions

Motivational InterviewBEHAVIORAL

Informational leaflet about the risks of high LDL-C and the importance of adherence to lipid-lowering medication in patients with coronary artery disease. Follow-up motivational interviewing at 1 and 6 months after discharge.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subject hospitalized for acute coronary syndrome (STEMI, NTEMI or unstable angina) * Subject currently on lipid-lowering therapy or prescribed lipid-lowering therapy at hospital discharge (statins and/or other agents) * Subject who is 18 years or older * Subject or legally authorized representative who is willing and capable of providing informed consent, participating in all associated study activities Exclusion Criteria: * Subject unable to communicate via telephone for study interviewing * Subject with contraindication to statin therapy * Subject with any medical disorder that would interfere with completion or evaluation of clinical study results

Locations (1)

AHEPA University Hospital

Thessaloniki, Greece

Outcomes

Primary Outcomes

Achievement of low-density lipoprotein cholesterol therapeutic goal, as specified by current practice guidelines (LDL-C <70 mg/dL or >50% reduction from baseline LDL-C)

Time frame: 12 months after discharge from hospital

Secondary Outcomes

Overall adherence to lipid-lowering regimen, reported as both a continuous and a binary outcome, by using the 4-item Morisky Medication-Taking Adherence Scale

Time frame: 12 months after discharge from hospital

Data from ClinicalTrials.gov

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