Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia

Inclusion Criteria: 1. Patients 55-75 years of age inclusive 2. Refractory angina CCS Class III or IV 3. At least 3 angina episodes per week 4. Diagnostic coronary angiogram in the past 12 months confirming the presence of coronary artery disease in patients who are not candidates for standard interventions (PCI or CABG) 5. Patients without significant and adequate reduction or relief of angina in spite of treatment with at least two functional classes of chronic anti-angina medication at the maximally tolerated dose. Functional classes of anti-angina medications include β-blockers, calcium channel blockers, nitrates, and metabolic modulators (i.e. ranolazine). Participants must have been on a stable anti-angina medication regimen for at least 4 weeks before signing the informed consent form. 6. Documented clinical evidence of inducible ischemia on stress testing within the past 6 months \[e.g. nuclear perfusion imaging (stress SPECT or PET), stress ECHO, stress MRI, stress ETT (≥1 mm ST Segment depression)\]. 7. Maximal exercise duration of 3-8 minutes on ETT (Modified Bruce Protocol), with patient physically unable to continue due to angina or angina equivalent (e.g. exhaustion/dyspnea), or when ETT is stopped by person administering the ETT. Patient develops ≥1mm ST segment depression on each of the qualifying baseline ETT 8. Left ventricular ejection fraction (LVEF) of ≥ 30% 9. Postmenopausal female patients, women of childbearing potential and men willing to use an effective contraception method while in the study and/or who agree not to become pregnant or make their partner pregnant throughout the study and during one year after administration of the study drug 10. Female subjects of childbearing potential who have a negative urine pregnancy test and are willing to use an acceptable form of birth control during the study. For the purpose of this study, a female of childbearing potential is a female who is not postmenopausal for greater than 2 years, has not had a tubal ligation, and has not had a hysterectomy. For the purpose of this study, the following are considered acceptable methods of birth control: * Oral contraceptives, contraceptive patches/implants * Intrauterine device (IUD) together with condom or spermicide for at least three months * Condom and spermicide * Abstinence with a documented second acceptable method of birth control should the subject become sexually active 11. Willing and able to comply with all study requirements, including adherence to the assigned strategy, medical therapy, and follow-up 12. Provided written informed consent Exclusion Criteria 1. Female patients who are pregnant, lactating (breast milk feeding), or planning a pregnancy during the course of the study and one year after administration of the study drug. Women of childbearing potential who are not using an acceptable method of birth control (i.e., IUD, oral contraceptive plus barrier contraceptive, hormone delivery system plus barrier contraceptive or condom in combination with contraceptive cream, jelly or foam). Women of childbearing potential with a positive urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) before randomization. 2. Patients with unstable angina for whom an immediate revascularization procedure (PCI or CABG) is indicated 3. Patients for whom a cardiac revascularization procedure (PCI or CABG) is planned in the next 3 months 4. Myocardial infarction within the past 3 months prior to the Screening visit 5. Congestive heart failure New York Heart Association (NYHA) Class IV 6. Myocarditis or restrictive pericarditis 7. Diagnostic coronary angiogram finding of left main coronary stenosis ≥70% (unless the patient has a patent graft or collateral vessels supplying the left coronary circulation) or proximal stenoses ≥70% in all major coronary conduit vessels (coronary arteries and bypass grafts) 8. A single patent coronary conduit (for example, totally occluded RCA and LCx with no bypass grafts. Patient will not tolerate balloon occlusion of the LAD for infusion) 9. Patients whose angiogram shows a good anatomy for angioplasty and who are candidates for that procedure. Patients without a prior angiogram or angiogram report are excluded. 10. Clinically significant aortic or mitral valvular heart disease 11. Life-threatening coronary ostial stenosis that precludes adequate catheter engagement in any target vessel, unless the vessel can be accessed via a patent bypass graft 12. Coronary artery to venous communications, which bypass the coronary capillary bed 13. Untreated life-threatening ventricular arrhythmias 14. Uncontrolled arterial hypertension with systolic blood pressure \>140 mm Hg and/or diastolic pressure \>100 mm Hg 15. CABG surgery within the past 6 months, unless those grafts are now occluded 16. Percutaneous coronary intervention (PCI) within the past 3 months, unless the stented/dilated vessel(s) are now occluded 17. Enhanced external counterpulsation (EECP) within 3 months prior to the start of screening evaluations 18. Prior treatment with spinal cord stimulation 19. Prior treatment with coronary sinus reducer 20. Transmyocardial or percutaneous myocardial laser revascularization within the past 12 months 21. Prior treatment with any cardiovascular gene or cell therapy within the past 12 months 22. Active SARS-CoV-2 infection (COVID-19) 23. Any major organ disease or any medical disease or condition that substantially impairs life expectancy 24. History of cancer within the past 5 years, other than basal cell carcinoma, or patients with any laboratory or physical exam or diagnostic procedure finding suggestive of current malignancy 25. Moderate to severe non-proliferative or proliferative retinopathy from any cause, clinically significant macular edema, or previous pan-retinal photocoagulation therapy 26. Heparin induced thrombocytopenia or history of idiopathic thrombocytopenic purpura or other medical condition causing thrombocytopenia 27. Serum glutamic pyruvic transaminase (SGPT) level greater than 2.0 times the upper limit of the laboratory normal range. 28. Bilirubin level ≥ 2.0 mg/dL 29. Serum creatinine ≥ 2.5 mg/dL 30. Platelet count \< 100,000/μL 31. White blood cell count \< 3,000/μL 32. HbA1c \> 9% in patients with diabetes 33. Positive test for hepatitis B or C 34. Positive test for human immunodeficiency virus (HIV) 35. Prior anaphylaxis reaction to iodinated contrast agents 36. Patients who are known to be immunosuppressed or are receiving chronic treatment with immunosuppressive drugs 37. Received an investigational drug or biologic within 30 days of screening or are currently participating in an investigational drug, biologic or device trial 38. History of alcohol or drug abuse 39. History of non-compliance with medical therapy