Safety and Effectiveness of the Sight Sciences VISCO™360 Versus SLT in Primary Open Angle Glaucoma

Inclusion Criteria: * Diagnosed with primary open-angle glaucoma (POAG) in the study eye. * Pseudophakic with Posterior Chamber IOL (PCIOL) * Able and willing to attend follow up visits for two years post-operative * Able and willing to sign informed consent Exclusion Criteria: * Phakia or aphakia * Previous glaucoma procedure with or without an implantable glaucoma device (including incisional surgery, ALT, iridectomy/iridotomy, etc.) \[Subjects with one prior SLT application (\>3 months prior to screening) or prior ECP (performed \> 12 months prior to screening) can be enrolled\]. * Use of more than 3 ocular hypotensive medications (combination medications count as 2 medications) * Diagnosis of acute angle closure, traumatic, congenital, malignant, uveitic, pseudoexfoliative, pigmentary or neovascular glaucoma * Abnormal angle anatomy as determined by gonioscopy (e.g. peripheral anterior synechiae, rubeosis or other angle abnormalities) * Participation in any clinical trial ≤ 30 days prior to screening