A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics (PK) After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers

Inclusion Criteria: 1. Provision of signed and dated, written informed consent prior to any study specific procedures. 2. Healthy male subjects aged 18 to 55 years (inclusive) with suitable veins for cannulation or repeated venipuncture. 3. Have a body mass index (BMI) between 18 and 29.9 kg/m2 inclusive and weigh at least 50 kg and no more than 100 kg inclusive. 4. Subjects should be willing to follow reproductive restrictions to prevent pregnancy and drug exposure of a female partner and refrain from donating sperm or fathering a child from the first day of dosing until 3 months after the last dose of IMP. 5. Be able to inhale from the DPI devices according to given instructions. 6. Subjects must read, speak and understand German language. Exclusion Criteria: 1. History of any clinically significant disease or disorder which, in the opinion of the PI, may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer's ability to participate in the study. 2. History or presence of gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs. 3. Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of IMP. 4. Any clinically significant abnormalities in clinical chemistry, hematology or urinalysis results, at screening and first admission to the study unit as judged by the PI. 5. Any clinically significant abnormal findings in vital signs at screening and first admission to the study unit, as judged by the PI. Abnormal vital signs, after 10 minutes supine rest, defined as any of the following: - Systolic BP (SBP) \< 90 mmHg or \> 140 mmHg - Diastolic BP (DBP) \< 50 mmHg or \> 90 mmHg - Heart rate \< 45 or \> 90 beats per minute. 6. Any clinically significant abnormalities on 12-lead ECG at screening and first admission to the study unit, as judged by the PI. 7. Any positive result on screening for serum hepatitis surface antigen or antiHBc antibody suggestive of hepatitis B infection, hepatitis C antibody, and human immunodeficiency virus (HIV) antibody. 8. Known or suspected history of drug abuse, as judged by the PI. 9. Has received another new chemical entity (defined as a compound which has not been approved for marketing) within 3 months of the first administration of IMP in this study. The period of exclusion begins 3 months after the final dose or one month after the last visit whichever is the longest. Note: subjects consented and screened, but not randomized in this study or a previous phase I study, are not excluded. 10. Plasma donation within 1 month of screening or any blood donation/loss more than 500 mL during the 3 months prior to screening. 11. History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as judged by the PI or history of hypersensitivity to drugs with a similar chemical structure or class to AZD7594. 12. Current smokers or those who have smoked or used nicotine products within the 3 months prior to screening. 13. Subjects who are not able to perform correct spirometry tests at screening. 14. Subjects with forced expiratory volume at one second (FEV1) and forced vital capacity (FVC) \<80% predicted (calculated) values and FEV1/FVC ratio \<0.7 in pulmonary function test (spirometry) at Screening Visit. 15. Positive screen for drugs of abuse or cotinine at screening or on each admission to the study center or positive screen for alcohol on each admission to the study center. 16. Use of drugs with enzyme-inducing properties such as St John's Wort within 3 weeks prior to the first administration of IMP. 17. Use of any prescribed or non-prescribed medication including antacids, analgesics (other than paracetamol/acetaminophen), herbal remedies, megadose vitamins (intake of 20 to 600 times the recommended daily dose) and minerals during the 2 weeks prior to the first administration of IMP or longer if the medication has a long half-life. 18. Known or suspected history of alcohol or drug abuse or excessive intake of alcohol as judged by the PI. 19. Involvement of any AstraZeneca, PAREXEL or study site employee or their close relatives. 20. Subjects who have previously received AZD7594. 21. Judgment by the PI that the volunteer should not participate in the study if they have any ongoing or recent (i.e., during the screening period) minor medical complaints that may interfere with the interpretation of study data or are considered unlikely to comply with study procedures, restrictions, and requirements. 22. Vulnerable subjects, e.g., kept in detention, protected adults under guardianship, trusteeship, or committed to an institution by governmental or juridical order.