A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke

Inclusion Criteria: * Radiologic assessment confirming an acute middle cerebral artery ischemic stroke * Index stroke occurred within the past 3-4 days * Inpatient males and females * Severe hemiparesis or hemiplegia defined by FMMS score less than or equal to (\</=) 35 * Sufficient speech, vision and hearing to participate in study evaluations Exclusion Criteria: * NIHSS greater than (\>) 20 * Severe aphasia that prevents a participant from following directions in rehabilitation * Significant deficit from prior strokes or pre-existing motor deficit * History of epilepsy, neurosurgery, severe head trauma or central nervous system infections that have residual symptomatology or have required treatment in the last 12 months * Known or suspected clinical seizure post-index stroke * History of pre-existing dementia or use of medications for dementia * History of clinically significant pre-existing psychiatric conditions within 12 months prior to stroke * Due to undergo carotid surgery within the next 4 months * Enrollment/participation in any interventional study (clinical trial) involving an investigational drug (unapproved) or non-drug treatment within the prior 3 months or 6 times the half-life (whichever is longer) * Clinically relevant medical conditions that would likely interfere with the study conduct and scheduled assessments * Contraindication to magnetic resonance imaging (MRI) or conditions which render interpretation of MRI difficult