Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium

For the placebo and minocycline group; Inclusion Criteria: 1. Elder than 65 years old 2. Speak Chinese Mandarin 3. Those who will undergo major general surgery like colorectal cancer excision, major urinary surgery like radical prostatectomy and radical nephrectomy 4. Signed the inform consent 5. American Society of Anesthesiologists classification I to III Exclusion Criteria: 1. Existing cerebral disease, or have a history of neurological and psychiatric diseases including Alzheimer Disease, stroke, epilepsy and psychosis; 2. Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24; 3. Severe audition or vision disorder; 4. Unwillingness to comply with the protocol or procedures. 5. Cannot communicated with Chinese Mandarin 6. With severe skin disease 7. Serious heart or liver or renal insufficiency patients 8. Had surgery in the past 30 days 9. Allergy to tetracycline or minocycline For the health volunteers; Inclusion Criteria: 1. Elder than 65 years old 2. Speak Chinese Mandarin 3. Signed the inform consent 4. No major disease health people Exclusion Criteria: 1. Existing cerebral disease, or have a history of neurological and psychiatric diseases including Alzheimer Disease, stroke, epilepsy and psychosis; 2. Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24; 3. Severe audition or vision disorder; 4. Unwillingness to comply with the protocol or procedures. 5. Cannot communicated with Chinese Mandarin 6. Drug abuse, alcoholism 7. Serious heart or liver or renal insufficiency patients 8. Had surgery in the past 30 days 9. Plan to undergo surgery in the following 3 months.