Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.
The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.
Study Type
OBSERVATIONAL
Enrollment
1,101
University Hospital Zurich
Zurich, Switzerland
Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs
Do anticoagulants or antiplatelet drugs increase the risk of repeated bleeding in patients with gastrointestinal bleeding?
Time frame: 5 years
Patients with diabetes mellitus and systemic corticosteroids
Do systemic corticosteroids increase the risk of exacerbation in patients with diabetes mellitus?
Time frame: 5 years
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