The Core Body Temperature Rhythms: Distinguishing MCS From UWS

Jing Wang7 enrolled

Overview

In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .

Living beings have multicomponent biological rhythms. There was a research recorded 24-h virations in electroencephalographic patterns. In normal subjects, the circadian rhythms of core body temperature is close to 24 h. When the interference of environmental and mental elements were eliminated, circadian rhythm shows the endogenous circadian rhythm of body acquiescently (\>24h ), which is also called free-running period. Measuring the continuous external auditory canal temperature of 4 unresponsive wakefulness syndrome (UWS) and 3 minimally conscious state(MCS) on the fluorescent lamp surrounding every 2 hours for 168 hours starting at 00:00 on the first day to address circadian capabilities. Researchers expected to see the difference between MCS and UWS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Disorders of Consciousness

Eligibility

Sex: ALLMin age: 39 YearsMax age: 69 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients in minimally conscious state * patients with stable condition * patients free of sedative drugs and Na+ or Ca++ blockers (e.g., carbamazepine) or NMDA receptor antagonist (e.g., dextromethorphan) Exclusion Criteria: * premorbid neurology antecedent * patients in coma or vegetative state * patients \< 1 months after the acute brain injury

Outcomes

Primary Outcomes

Measuring the continuous external auditory canal temperature

VS patients have core body temperature periods which are longer than 24 hours; whereas MCS patients are shorter than 24 hours.

Time frame: Continuous temperature measurements for 168 hours (8days)

Data from ClinicalTrials.gov

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