Evaluation of the Efficacy of Platelet-rich Plasma (PRP) on Advanced Endoscopic Resection Techniques

Germans Trias i Pujol Hospital11 enrolled

Overview

To avoid complications secondary to advanced endoscopic resection techniques (Endoscopic Mucosal Resection -EMR- or Endoscopic Submucosal Disection -ESD-) the endoscopists have to avoid deep thermal damage and increase mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in preclinical endoscopic resection models.

Background:To avoid complications secondary to advanced endoscopic resection techniques (Endoscopic Mucosal Resection -EMR- or Endoscopic Submucosal Disection -ESD-) the endoscopists have to avoid deep thermal damage and increase mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in preclinical endoscopic resection models. Aim: Evaluate the efficacy of PRP on participants submitted to advanced endoscopic resection techniques: EMR or ESD. Material and Methods: The investigators have evaluated a prospective clinical study. The investigators have included 12 participants submitted to EMR or ESD. Patients were informed and accepted to participate with a written consent. Prior to endoscopy PRP was obtained from autologous blood with a comercial kit. Submucosal injection with PRP were performed prior to resection. Resection was performed with standard technique. Participants were followed-up after the procedure.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Platelet-rich Plasma Endoscopic Mucosal Resection Endoscopic Submucosal Dissection

Interventions

Platelet-rich plasmaDRUG

Submucosal injection with PRP was performed prior to endoscopic resection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Endoscopic lesion higher than 40mm in diameter submitted to endoscopic resection (EMR or eSD) Exclusion Criteria: * Ineligibility to endoscopic resection

Locations (1)

Endoscopy Unit. University Hospital Germans Trias

Badalona, Barcelona, Spain

Outcomes

Primary Outcomes

Prevention of delayed bleeding: percentage of participants with delayed bleeding

Delayed bleeding occurs between 13-15% of patients submitted to advanced resection techniques. The aim of this study is to evaluate the efficacy of PRP in the prevention of this complication

Time frame: 28 days after resection

Prevention of coagulation syndrome (or postpolipectomy syndrome): percentage of participants with coagulation syndrome

Coagulation syndrome occurs in around 5-7% of patients submitted to EMR or ESD. The aim is to evaluate the efficacy of PRP in the prevention of this complication

Time frame: 5 days after resection

Data from ClinicalTrials.gov

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