The purpose of this study is to determine the glycemic index of commonly consumed sweeteners.
This three arm study is intended to add to scientific knowledge by providing accurate assessments of the glycemic index commonly consumed food items. This will be used in the scientific literature to assess the glycemic index of foods containing various sweeteners. Participants will be monitored for a total of 10 weeks. The glycemic index is defined as the "incremental area under the glucose response curve after standard amount of carbohydrate relative to that of a control food (white bread or glucose) is consumed." In general, the glycemic index quantifies the relative effect of the carbohydrate content of the food on resultant blood glucose.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
12
For each OGTT, subjects will consume 50g of sweetener dissolved in water at a comfortable pace within 10 minutes. Blood samples for plasma glucose and insulin will be taken at -20, 0, 15, 30, 45, 60, 90 and 120 min after consuming the glucose drink. Plasma fructose will be tested at baseline, 30, 60, 90 and 120 minutes.
Yale Center for Clinical Investigation Church Street Research Unit
New Haven, Connecticut, United States
Mean Glycemic Index
The mean glycemic index of participants will be calculated by averaging the 3 calculated glycemic index values for each of the 3 types of sweetener. Each participant will be randomly given 1 of 3 the commonly consumed sweeteners three different times over a nine week period- for a total of 3 observations per arm. Glycemic index is measured by giving test subjects the commonly consumed sweetener, and then measuring blood glucose response over a two hour time period using an Oral Glucose Tolerance Test. That response is then compared against a reference (glucose) and averaged across all subjects to get a relative index value. The glycemic index (GI) is a ranking of carbohydrates on a scale from 0 to 100 according to the extent to which they raise blood sugar levels after eating. (http://www.glycemicindex.com/about.php)
Time frame: 2 hours
Body Mass Index (BMI)
BMI will be captured at the baseline visit, it will calculated using the formula Weight in Kilograms / ( Height in Meters x Height in Meters)
Time frame: Baseline
Body Mass Index (BMI)
BMI will be captured at the 9 weeks visit, it will calculated using the formula Weight in Kilograms / ( Height in Meters x Height in Meters)
Time frame: 9 weeks
Percent Fat Mass
Percent fat mass at baseline will be captured using the Tanita Body Fat Analyzer.
Time frame: Baseline
Percent Fat Mass
Percent fat mass at 9 weeks will be captured using the Tanita Body Fat Analyzer.
Time frame: 9 weeks
Total Fat Mass
Total fat mass at baseline will be captured using the Tanita Body Fat Analyzer.
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Time frame: Baseline
Total Fat Mass
Total fat mass at 9 weeks will be captured using the Tanita Body Fat Analyzer.
Time frame: 9 weeks