Effect of Bacopa Monnieri on Working Memory and Cognitive Processing in Student

Khon Kaen University75 enrolled

Overview

The purpose of this study is to determine the effect of Bacopa Monnieri on working memory and cognitive processing in student.

Learning and working memory are two of the key role for studying and work successful for student particular the high school student who study hard and preparing themselves for the graduate study. The consumption of brain booster product or functional food for improving memory has gained much attention. It has been reported that Bacopa Monnieri could improve learning and working memory in elderly subject by improving the N100 and P300 event related potential. Therefore, Bacopa Monnieri might be the potential product for improving the learning and working memory in student particular high school student.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

PlaceboDIETARY_SUPPLEMENT

Subjects are received Placebo once daily for 16 weeks.

Bacopa Monnieri 300 mg/dayDIETARY_SUPPLEMENT

Subjects are received Bacopa Monnieri at the dose of 300 mg/day once daily for 16 weeks.

Bacopa Monnieri 600 mg/dayDIETARY_SUPPLEMENT

Subjects are received Bacopa Monnieri at the dose of 600 mg/day once daily for 16 weeks.

Eligibility

Sex: ALLMin age: 15 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy student subject aged between 15-18 years old who studying in the school within Khon Kaen province. * Body mass index is between 18.5-24.9 Exclusion Criteria: * Subjects who are diagnosed with one of the following: cardiovascular diseases, respiratory disease, neuropsychological diseases, head injury, diabetes mellitus, liver disease, cancer, autoimmune disease and hematological disorder are excluded. * Subjects who take any medicine or nutraceuticals or hormone that effect on central nervous system are excluded. * Alcohol addict or smoking addiction (more than 10 pieces/day) * Athlete or subjects who have a regular exercise more than 3 times/week * Subjects who don't follow the instruction during the trial * Subjects who are participating the other project.

Locations (1)

Jitanaporn Wattanathorn

Khon Kaen, Thailand

Outcomes

Primary Outcomes

Cognitive processing using the latency of P300 wave

The latency of P300 wave was measured and expressed as millisecond.

Time frame: 4 months

Cognitive processing using the amplitude of P300 wave

The amplitude of P300 wave was measured and expressed as micro-volt.

Time frame: 4 months

Attention using the latency of N100 wave

The latency of N100 wave was measured and expressed as millisecond.

Time frame: 4 months

Attention using the amplitude of N100 wave

The amplitude of N100 wave was measured and expressed as micro-volt.

Time frame: 4 months

Secondary Outcomes

Accuracy of working memory using computerized battery test

The accuracy of working memory was determined and expressed as percentage.

Time frame: 4 months

Speed of working memory using computerized battery test

The speed of working memory was determined and expressed as millisecond.

Time frame: 4 months

Assessment of psychiatric symptoms using the symptom check list 90 (SCL-90)

Time frame: 4 months

Assessment of mood scale using Bond-Lader visual analogue scales

Time frame: 4 months

Acetylcholinesterase activity in serum

Data from ClinicalTrials.gov

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