Effects of Propofol and Ketofol on Core Body Temperature in MRI

Istanbul University90 enrolled

Overview

Investigators researched the effect of two different types of drugs on core body temperature during magnetic resonance imaging. The hypothesis is in ketamine group, thermo disregulation is not as distinct as in propofol group, due to its positive effect on thermo regulation

Intravenous anesthetics may impair thermoregulation. Absorption of radiofrequency waves by the body surface may result in heating, especially in small children during magnetic resonance imaging (MRI). Investigators applied two different intravenous anesthetics as propofol and ketamine and studied the effect of these drugs on core body temperature. All patients aged between 6 months-10 years were administered midazolam and atropine. After that 1 mg/ kg of propofol was applied in group I, and 0,1 ml/kg of propofol ketamine mixture ( 10 mg/ml each) was applied in group II. Core body temperatures were taken before and after MRI and compared.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Children

Interventions

propofolDRUG

propofol, midazolam and atropine administration via intravenous cannula.

Ketamine propofol mixtureDRUG

Administration of ketamine propofol mixture, midazolam and atropine via intravenous cannula

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 10 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * children aged between 6 months-10 years, * underwent MRI under anesthesia * ASA I-II Exclusion Criteria: * History of drug allergy * Severe pulmonary and cardiac disease * Intracranial hypertension

Outcomes

Primary Outcomes

Change in core body temperature

temperature was taken from tympanic membrane bilaterally before and after MRI. If temperature change was more or les than 0.1 degrees celsius the patient was considered as warmer or cooler.

Time frame: during magnetic resonance imaging (MRI) procedure

Data from ClinicalTrials.gov

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