Medication-related Osteonecrosis of the Jaw (MRONJ) Registry

Inclusion Criteria: * Age \> 18 years * Newly diagnosed patients with osteonecrosis in a facial bone other than the jaw, or * Newly diagnosed patients with non-exposed MRONJ (stage 0), or * Newly diagnosed patients with exposed MRONJ, i.e: * Current or previous treatment with antiresorptive or antiangiogenic agents. * Exposed bone or bone that can be probed through an intraoral or extraoral fistula(e) in the maxillofacial region that has persisted for more than 8 weeks * No history of radiation therapy to the jaws or obvious metastatic diseases of the jaw * Ability to understand the content of the patient information/ Informed Consent Form * Willingness and ability to participate in the clinical investigation according to the Registry Plan (RP) * Signed and dated IRB/EC-approved written informed consent * Mental capacity to comply with post-operative regimen, evaluation and data collection Exclusion Criteria: * Recent history of substance abuse (i. e., recreational drugs, alcohol) that would preclude reliable assessment * Pregnancy or women planning to conceive within the registry period * Prisoner * Participation in any other medical device or medicinal product study within the previous month that could influence the results of the present registry