Post Infarction Exercise Effects on Myocardial Function Assessed by 2D Strain Ultrasound

Centre Hospitalier Universitaire de Nīmes65 enrolled

Overview

The main goal of our project is to study and describe the effect of exercise training on systolic and diastolic myocardial function assessed by 2D ultrasound strain after myocardial infarction. Our working hypothesis is that the intrinsic myocardial contractility and relaxation assessed by global longitudinal strain in phase II (or 2D strain) during post-infarction exercise training will be improved compared to baseline values as well as compared to values in a no-training group. Should this hypothesis prove true, it would help explain the improvements in functional capacity observed during the post-infarction period and after exercise training.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Myocardial Infarction

Interventions

This program takes place at the Cardiovascular Rehabilitation Department at the Nîmes University Hospital and includes a combination of various physical activities: treadmill, exercise bike, rower, aerobics, gymnastics, serious games, swimming. The program begins approximately within 3 months after myocardial infarction and consists of 20 consecutive days of training. The main physical activity is aerobic interval training (AIT). 30-minute AIT sessions will occur 5x per week for 4 weeks. 1 AIT session includes a warm up for 8 minutes to reach a heart rate during exercise corresponding to 20 to 30% of maximum aerobic power determined during the initial effort test. Then interval training occurs with 4x2 min of high intensity effort (heart rate during exercise corresponding to 80% of maximum aerobic power) alternating with 2 min of active recovery at 20-30% of maximum aerobic power. Then recovery for 8 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan * The patient is available for 4 months of follow-up * The patient had a first myocardial infarction episode (within the past 3 months) requiring medical treatment or revascularisation (e.g. balloon angioplasty) or aortocoronary bypass Exclusion Criteria: * The patient is simultaneously participating in (or has participated in the past 3 months) another interventional study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection or under guardianship * It is impossible to correctly inform the patient or the patient refuses to sign the consent * The patient is pregnant, parturient, or breastfeeding * Contra indication for exercise training * Valve prosthesis * Severe valvular disease * Pacemaker * Heart transplant * Non sinus rhythm

Outcomes

Primary Outcomes

The % global longitudinal strain of the left ventricle

Time frame: within 3 months post infarction = T0 (baseline)

The % global longitudinal strain of the left ventricle

Time frame: 5 weeks

The % global longitudinal strain of the left ventricle

Time frame: 3 months

Secondary Outcomes

maximal oxygen consumption (VO2max; mL/min/kg)

Time frame: within 3 months post infarction = T0 (baseline)

maximal oxygen consumption (VO2max; mL/min/kg)

Time frame: T0 + 5 weeks

maximal oxygen consumption (VO2max; mL/min/kg)

Time frame: T0 + 3 months

maximum aerobic power (watts)

Time frame: within 3 months post infarction = T0 (baseline)

maximum aerobic power (watts)

Time frame: T0 + 5 weeks

maximum aerobic power (watts)

Time frame: T0 + 3 months

First ventilatory threshold (mL/min/kg)

Time frame: within 3 months post infarction = T0 (baseline)

First ventilatory threshold (mL/min/kg)

Time frame: T0 + 5 weeks

First ventilatory threshold (mL/min/kg)

Time frame: T0 + 3 months

left ventricle longitudinal systolic strain rate

Time frame: within 3 months post infarction = T0 (baseline)

left ventricle longitudinal systolic strain rate

Time frame: T0 + 5 weeks

left ventricle longitudinal systolic strain rate

Time frame: T0 + 3 months

left ventricle longitudinal diastolic strain rate

Time frame: within 3 months post infarction = T0 (baseline)

left ventricle longitudinal diastolic strain rate

Time frame: T0 + 5 weeks

left ventricle longitudinal diastolic strain rate

Time frame: T0 + 3 months

% radial systolic strain

Time frame: within 3 months post infarction = T0 (baseline)

% radial systolic strain

Time frame: T0 + 5 weeks

% radial systolic strain

Time frame: T0 + 3 months

% radial diastolic strain

Time frame: within 3 months post infarction = T0 (baseline)

% radial diastolic strain

Time frame: T0 + 5 weeks

% radial diastolic strain

Time frame: T0 + 3 months

% circumferential systolic strain

Time frame: within 3 months post infarction = T0 (baseline)

% circumferential systolic strain

Time frame: T0 + 5 weeks

% circumferential systolic strain

Time frame: T0 + 3 months

% circumferential diastolic strain

Time frame: within 3 months post infarction = T0 (baseline)

% circumferential diastolic strain

Time frame: T0 + 5 weeks

% circumferential diastolic strain

Time frame: T0 + 3 months

Radial systolic strain rate

Time frame: within 3 months post infarction = T0 (baseline)

Radial systolic strain rate

Time frame: T0 + 5 weeks

Radial systolic strain rate

Time frame: T0 + 3 months

Radial diastolic strain rate

Time frame: within 3 months post infarction = T0 (baseline)

Radial diastolic strain rate

Time frame: T0 + 5 weeks

Radial diastolic strain rate

Time frame: T0 + 3 months

Circumferential systolic strain rate

Time frame: within 3 months post infarction = T0 (baseline)

Circumferential systolic strain rate

Time frame: T0 + 5 weeks

Circumferential systolic strain rate

Time frame: T0 + 3 months

Circumferential diastolic strain rate

Time frame: within 3 months post infarction = T0 (baseline)

Circumferential diastolic strain rate

Time frame: T0 + 5 weeks

Circumferential diastolic strain rate

Time frame: T0 + 3 months

Telediastolic volume (mL)

Time frame: within 3 months post infarction = T0 (baseline)

Telesystolic volume (mL)

Time frame: T0 + 5 weeks

Telesystolic volume (mL)

Time frame: T0 + 3 months

Telediastolic volume (mL)

Time frame: T0 + 5 weeks

Telediastolic volume (mL)

Time frame: T0 + 3 months

Left ventricle mass (g/m^2)

Time frame: within 3 months post infarction = T0 (baseline)

Left ventricle mass (g/m^2)

Time frame: T0 + 5 weeks

Left ventricle mass (g/m^2)

Time frame: T0 + 3 months

Ejection fraction of the left ventricle

Time frame: within 3 months post infarction = T0 (baseline)

Ejection fraction of the left ventricle

Time frame: T0 + 5 weeks

Ejection fraction of the left ventricle

Time frame: T0 + 3 months

S' wave velocity (cm/s)

Time frame: within 3 months post infarction = T0 (baseline)

S' wave velocity (cm/s)

Time frame: T0 + 5 weeks

S' wave velocity (cm/s)

Time frame: T0 + 3 months

E' wave velocity (cm/s)

Time frame: within 3 months post infarction = T0 (baseline)

E' wave velocity (cm/s)

Time frame: T0 + 5 weeks

E' wave velocity (cm/s)

Time frame: T0 + 3 months

A' wave velocity (cm/s)

Time frame: within 3 months post infarction = T0 (baseline)

A' wave velocity (cm/s)

Time frame: T0 + 5 weeks

A' wave velocity (cm/s)

Time frame: T0 + 3 months

The E/A ratio

Time frame: within 3 months post infarction = T0 (baseline)

The E/A ratio

Time frame: T0 + 5 weeks

The E/A ratio

Time frame: T0 + 3 months

Post Infarction Exercise Effects on Myocardial Function Assessed by 2D Strain Ultrasound

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes