The Efficacy of Probe-based Confocal Laser Endomicroscopy in Staging OLGIM

Shandong University30 enrolled

Overview

Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis. Though important, it is not necessary to recommend surveillance endoscopy for all patients with GIM, since the progression rate to gastric cancer within 10 years is only 1.8% in those patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Probe-based Confocal Laser Endomicroscopy the Operative Link on Gastric Intestinal Metaplasia

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 40 years or older with Helicobacter pylori infection; * Histologically verified GIM, atrophic gastritis or dysplasia. Exclusion Criteria: * Patients with gastrectomy, acute GI bleeding and advanced gastric cancer; * Conditions unsuitable for performance of pCLE, such as coagulopathy, impaired renal function or allergy to fluorescein sodium; * Pregnancy or breastfeeding; * Inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.

Outcomes

Primary Outcomes

the sensitivity of probe-based Confocal Laser Endomicroscopy (pCLE) in staging the Operative Link on Gastric Intestinal Metaplasia (OLGIM).

Time frame: 6 months

the of specificity of probe-based Confocal Laser Endomicroscopy (pCLE) in staging the Operative Link on Gastric Intestinal Metaplasia (OLGIM).

Time frame: 6 months

Secondary Outcomes

the of sensitivity of probe-based Confocal Laser Endomicroscopy (pCLE) in staging Gastric Intestinal Metaplasia (GIM).

Time frame: 6 months

the of specificity of probe-based Confocal Laser Endomicroscopy (pCLE) in staging Gastric Intestinal Metaplasia (GIM).

Time frame: 6 months

Central Contacts

Li Yanqing, MD, PhD

CONTACT

86-531-82169236 liyanqing@sdu.edu.cn

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.