Liposomal Bupivacaine in Ambulatory Hand Surgery

Loma Linda University

Overview

This study is being done to evaluate pain management regimens following ambulatory hand surgery. Improved pain control may be associated with decreased complications, decreased pain scores, decreased opioid dependence, improved patient comfort and satisfaction, and reduced healthcare costs. Liposomal bupivacaine is an FDA-approved local anesthetic. There will be two groups. One group will receive liposomal bupivacaine. One group will not. The results will be compared. Patients will be over the age of 18 ambulatory hand surgery. Approximately 40 subjects will participate in this study at LLU.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Pain

Interventions

Liposomal BupivicaineDRUG

Patients in Group 2 (Liposomal Bupivacaine + Plain Bupivacaine) will be treated intra-operatively with the initial injection of 0.25% bupivacaine 5 - 10 mL (12.5 - 25 mg) delivered to perform a field block of the soft tissue and subfascial plane at the initiation of the procedure.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients 18 years of age and over undergoing ambulatory hand surgery involving soft tissue and subfascial structures, including: CMC arthritis, flexor and extensor tendon injury, symptomatic ganglia, hand and finger fractures Exclusion Criteria: * Patients who are unable to give informed consent to participate in this study * Patients with a documented history of hypersensitivity reactions to local anesthetic agents * Patients with a diagnosis of chronic pain disorders such as fibromyalgia, chronic migraine headaches, or psychiatric disorders other than depression or anxiety * Patients who are currently pregnant * Patients with impaired hepatic function * Patients with underlying nerve damage or impairment * Patients with renal impairment/failure * Patients whose career/livelihood require a great deal of hand dexterity, in whom a complication could cause a significant impact on life and career (ex: musician, dentist)

Locations (1)

Loma Linda University

Loma Linda, California, United States

Outcomes

Primary Outcomes

Post-operative Opioid Use

Patients will record their opioid use post-operatively

Time frame: At scheduled intervals up to 168 hours post-operatively

Data from ClinicalTrials.gov

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