Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer

Inclusion Criteria: * Patients with locally advanced primary and recurrent colorectal cancer (CRC) (histologically or cytologically confirmed adenocarcinoma), with a confirmed oncogenic KRAS exon 2, codon 12 or 13 mutations, eligible for radical pelvic surgery at time of enrolment. * Patient is ≥18 years of age and able to consent * Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1 * Patient has adequate organ and bone marrow function within 28 days of study * Neutrophil count \>1.5 x10\^9/L * Platelets \>100 x10\^9/L * Hb \>90g/L * Total bilirubin \<1.5 upper limit of normal, ULN * ALT and AST \<3.0 x ULN * Serum creatinine \<3 x ULN or Creatinine Clearance ≥ 30ml/min (Cockroft-Gault or Nuclear GFR method) * PT and APTT \<1.3 x ULN * The patient is willing to provide study specific pre TG02-treatment biopsy of tumour mass and allow use of archival tumour biopsies. For patients where there are technical reasons a baseline biopsy cannot be performed but who fulfil all the other inclusion criteria, the investigator shall contact the medical monitor to discuss the possibility of including such patient. * The patient is willing and able to comply with the protocol, and agrees to return to the hospital for study visits and examinations * Men and women of childbearing potential must use adequate contraception to prevent pregnancy during the study. Adequate contraception is defined in the study as any medically recommended method (or combination of methods) as per standard of care. An adequate contraception includes hormonal contraception with implants or combined oral, transdermal or injectable contraceptives, certain intrauterine devices, bilateral tubal ligation, hysterectomy, or vasectomy of partner. A combination of male condom with either cap, diaphragm or sponge with spermicide are also considered acceptable. For women of childbearing potential a negative pregnancy test needs to be confirmed before inclusion. * The patient has been fully informed about the study and is willing to participate in the study, and has provided written informed consent form prior to any trial specific screening procedures. Exclusion Criteria: * The patient has previously received an anticancer vaccine or immune checkpoint inhibitor, or participated in a trial involving the use of an anticancer vaccine or immune checkpoint inhibitor * Patients where pre-surgery radiotherapy, chemotherapy or other anti-cancer therapy has not been completed ≥ 2 weeks prior to TG02-treatment * The patients is receiving anti-cancer therapy for concurrent illness * The patient has had a prior different malignancy within the last 3 years (excluding adequately treated basal cell or squamous cell carcinoma of the skin cancer, or localised low grade tumours considered cured and not requiring systemic therapy) * The patient has uncontrolled or significant intercurrent or recent illness including: * auto-immune disorder or history of autoimmune disease requiring immunosuppressive treatment. * cardiac disorder such as uncontrolled cardiac failure, unstable angina or non-ST segment elevation myocardial infarction (NSTEMI) or myocardial infarction, uncontrolled arrhythmia less than 3 months before screening * stroke or thromboembolic event within 3 months of study commencement * active or uncontrolled severe infection * history of solid organ transplantation or any condition requiring chronic treatment with corticosteroids or other immunosuppressive agents * active coagulopathy/bleeding diathesis * cirrhosis, chronic active or untreated persistent hepatitis * history of adverse reactions to peptide vaccines * The patient is pregnant or lactating. * Has received an investigational drug within 4 weeks prior to study drug administration, or unless other has been agreed with the medical monitor * Is currently receiving any agent with a known effect on the immune system, unless at dose levels that are not immunosuppressive (e.g. prednisone at 10 mg/day or less or as inhaled steroid at doses used for the treatment of asthma) * Known history of positive tests for HIV/AIDS * Are planned to receive yellow fever or other live (attenuated) vaccines during the course of study * For Part II - any contraindication to receiving pembrolizumab: If using the 50 mg lyophilized powder; hypersensitivity to the active substance (pembrolizumab) or to any of the excipients; L-histidine, L-histidine hydrochloride monohydrate, Sucrose, Polysorbate 80. If using the 100 mg concentrate; hypersensitivity to the active substance (pembrolizumab) or to any of the excipients; L-histidine, Sucrose, Polysorbate 80