The Wellness Monitoring for Major Depressive Disorder (MDD) study is a prospective, longitudinal, observational study aimed at identifying biomarkers of relapse in MDD. Results may help refine clinical approach to relapse management, and may ultimately help MDD patients sustain wellness while on antidepressant medication.
This study involves a naturalistic follow up of responders from the study entitled "Integrated biological markers for the prediction of treatment response in depression", or the CAN-BIND-1 study. In addition, this study is also open to other participants who completed other CAN-BIND studies, as well as remitters who meet the inclusion criteria. Since patients usually seek medical attention only after relapse has occurred, imminent precursors to relapse are not well known. In this study, participants who are currently responding to an oral antidepressant treatment regimen and/or therapeutic intervention will be monitored over a minimum period of 13 months, which provides a unique opportunity to discover near-term biomarkers of relapse. The study is conducted in partnership with Janssen Research \& Development and utilizes remote monitoring technology for data gathering.
Study Type
OBSERVATIONAL
Enrollment
100
University of Calgary
Calgary, Alberta, Canada
University of British Columbia
Vancouver, British Columbia, Canada
McMaster University
Hamilton, Ontario, Canada
Queen's University
Kingston, Ontario, Canada
Rate of MDD Patients with Near Term Relapse
Relapse is defined as: 1. MADRS total score equal to or greater than 22 on at least 2 consecutive visits (scheduled or unscheduled); 2. Hospitalization for worsening of depression; 3. Suicidal ideation with intent, or suicidal behaviour; 4. Others. Investigators will be asked to describe.
Time frame: Baseline up to the one year enrolment period for the last-subject-in.
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University Health Network
Toronto, Ontario, Canada