The overarching aim of this project is to conduct a randomized controlled study to determine whether Mindfulness-Oriented Recovery Enhancement (MORE) vs. a Support Group (SG) can improve pain regulation and hedonic functions (i.e., natural reward responsiveness) thought to be governed by the endogenous opioid system among opioid-treated, chronic, non-neuropathic back pain patients (CNBP) and thereby improve clinical pain, affect, and opioid use.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
17
Mindfulness-Oriented Recovery Enhancement (MORE) is a group behavioral intervention that unites mindfulness training, cognitive reappraisal, and positive psychological principles into an integrative intervention strategy targeting mechanisms of pain and opioid misuse.
A conventional support group will allow participants to express emotions, share experiences, and receive social support under the guidance of a skilled therapist.
College of Social Work
Salt Lake City, Utah, United States
Changes in endogenous opioid system function in response to pain challenge
PET opioid receptor binding potential from baseline through pain challenge
Time frame: Change from week 0 to 8 weeks
Changes in fMRI activity level during natural reward processing
Blood oxygen dependent signal (BOLD) response during viewing and regulating response to natural reward cues measured during a fMRI scan.
Time frame: Change from week 0 to 8 weeks
Pain sensitivity as a measure of volume of hypertonic saline
Volume of hypertonic saline to maintain pain at 40 out of 100 on a VAS
Time frame: Change from week 0 to 8 weeks
Self-report affect ratings
Time frame: Change from week 0 to 8 weeks
Significant correlation between PET and fMRI measures with improvements in clinical pain, affect, and opioid use
Time frame: Change from week 0 to 8 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.