4 Cities for Assessing CAlcification PRognostic Impact After TAVI

Hospices Civils de Lyon1,600 enrolled

Overview

Transcatheter Aortic Valve Implantation (TAVI) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure. Despite a high rate of procedural success, some patients do not benefit from the procedure. The investigators hypothesis is that aortic stiffness may be of major prognostic significance after stenosis relief. The aim of this study is to test the prognostic impact of aortic stiffness estimated by the volume of calcifications of the thoracic aorta on the CT-scan performed systematically before the procedure. This prognostic value will be assessed in 4 independent cohorts issued from 4 french cities (Lyon, Rouen, Paris, Clermont-Ferrand).

Study Type

OBSERVATIONAL

Enrollment

1,600

Conditions

Heart Disease

Interventions

Transcatheter Aortic Valve Implantation (TAVI)DEVICE

TAVI is a well-accepted method for aortic valve replacement without surgery. It is currently proposed to patients at high surgical risk or contraindicated to surgery. It consists of introducing a valve inserted inside a stent by the femoral artery in most cases. Aortic calcifications will be determined by the analysis of the CT-scan performed systematically before the procedure. A semi-automated software (CreaTools) will be used

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 * Patient who underwent a transcatheter aortic valve implantation * Patient who provided informed, written consent to participate to FRANCE TAVI study * Patient for whom a CT-Scan performed before TAVI procedure is available. Exclusion Criteria: * none