Diabetic and nondiabetic patients will be evaluated if they had a first diagnosis of non-valvular atrial fibrillation and in therapy with non-vitamin K oral anticoagulants and with vitamin K oral anticoagulants.
Parameters evaluated: * anthropometric indices * glycated haemoglobin, basal and postprandial glycemia * lipid profile * small and dense LDL; oxidized LDL * I troponin * red and white cells count; platelets count * creatinin, transaminases, iron * fibrinogen, D-dimer, anti-thrombin III * Hs-CRP, metalloproteinases 2 and 9 * incidence of bleeding
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
IRCCS Policlinico San Matteo
Pavia, Italy
Efficacy on coagulation parameters
Red cells count
Time frame: 12 months
Efficacy on coagulation parameters
Platelets count
Time frame: 12 months
Efficacy on coagulation parameters
fibrinogen
Time frame: 12 months
Efficacy on coagulation parameters
D-dimer, anti-thrombin III
Time frame: 12 months
Bleeding risk
HAS-BLED score
Time frame: 12 months
Inflammation parameters
Hs-CRP
Time frame: 12 months
Inflammation parameters
White cells count
Time frame: 12 months
Endothelial damage
Metalloproteinases 2 and 9
Time frame: 12 months
Oxidative status
Small and dense LDL; oxidized LDL
Time frame: 12 months
Heart damage
I troponin
Time frame: 12 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Safety and tolerability parameters
Serum creatinin
Time frame: 12 months
Safety and tolerability parameters
Serum transaminases
Time frame: 12 months
Safety and tolerability parameters
Plasma iron
Time frame: 12 months