This study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (SAA) or acute wheeze that have been identified in retrospective studies. Secondary we will assess short-term medical and psychosocial functioning in patient (and parents) admitted to a PICU for SAA/acute wheeze versus a control group admitted to a MC for SAA/acute wheeze.
Study Type
OBSERVATIONAL
Enrollment
221
Erasmus MC
Rotterdam, South Holland, Netherlands
Undertreatment in children admitted to a PICU with a diagnosis of SAA/acute wheeze
Undertreatment is defined as: Patient is not using inhaled corticosteroids (ICS), or Patient is using ICS \< 7 days (counting from moment of admission to emergency department) according to treatment plan, or Patient is not using ICS according tot treatment plan.
Time frame: Within the time of admission on the PICU/MC, preferably within 48 hours and during follow up after 3-6 months
Exposure to triggers (single or combined)
Pollution/airborne particulate matter (PM10), sensitization/allergen exposure, cigarette smoke exposure (measured by cotinine in urine), presence and type of virus in upper airway tract
Time frame: Within the time of admission on the PICU/MC, preferably within 24 hours
Socio-economic status
Time frame: Within the time of admission on the PICU/MC
Frequency of previous asthma-related hospital admissions and/or PICU admissions.
Time frame: Within the time of admission on the PICU/MC and during follow up after 3-6 months
Severity of disease, defined using the GINA criteria for stepwise management of asthma.
Time frame: Within the time of admission on the PICU/MC, preferably within 48 hours and during follow up after 3-6 months
Distribution of ADRB2-receptor polymorphisms compared to non-SAA population.
Time frame: Through study completion, preferably within the time of admission on the PICU/MC
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