Study to Assess the Effect of the Aerobika Device in Addition to Standard of Care Treatment in Sputum Producing COPD Patients Using FRI

Inclusion Criteria: 1. Male or female subject ≥ 40 and ≤ 85 years old. 2. Written informed consent obtained. 3. Subject with a documented diagnosis of COPD with GOLD II to IV severity according to the GOLD guidelines, 4. Subject with a cooperative attitude and ability to be trained to correctly use the Aerobika® device. 5. Female subject t of childbearing potential must confirm that a contraception method was used at least 14 days before Visit 1 and will continue to use a contraception method during the study. 6. Subject must be sputum producing and treated in accordance with the GOLD guidelines. Sputum producing subjects are defined as patients who report productive cough with sputum "several days a week" (\>2 days a week) or "almost every day" in the month prior to the study. 7. Subject must be able to understand and complete the protocol requirements, instructions and protocol-stated restrictions. 8. Subject must use standard of care treatment. The regime of standard of care treatment must be on a stable dose of medication at least 1 week before Visit 1. 9. Subject should have unchanged smoking status within 3 months of Visit 1 and throughout the study period. Exclusion Criteria: 1. Pregnant or lactating female. 2. Subject with upper or lower airway infection that has not resolved within 4 weeks of the Screening Visit. 3. Subject experiencing an exacerbation defined as an acute change in the patient 's baseline dyspnea, cough, and/or sputum that is beyond normal day to day variations and necessitates the administration or doubling of systemic corticosteroid treatment within 4 weeks of the Screening Visit. 4. Subjects unable to tolerate the increased work of breathing. 5. Subject with a history of cerebrovascular disease 6. Patient with clinical significant hemodynamic instability (i.e. blood pressure instability). 7. Subject with recent facial, oral, or skull surgery or trauma. 8. Subject with active acute sinusitis. 9. Subject with active epistaxis (i.e. bleeding nose). 10. Subject with a history of esophageal surgery. 11. Subject with an active diagnosis of nausea on Visit 1. 12. Subject with active hemoptysis (i.e. bleeding from lungs). 13. Subject with untreated pneumothorax (i.e. untreated collapsed lung). 14. Subject with known or suspected tympanic membrane rupture or other middle ear pathology. 15. Subject unable to perform pulmonary function testing. 16. Subject with an uncontrolled disease or any condition that might, in the judgement of the investigator, place the patient at undue risk or potentially compromise the results or interpretation of the study. 17. Subject with active cancer or any other chronic disease with poor prognosis and /or affecting patient status 18. Subject unlikely to comply with the protocol or unable to understand the nature, scope, and possible consequences of the study. 19. Subject who received any investigational new drug within 4 weeks of Visit 1 or twice the duration of the biological effect of any drug (whichever is longer). 20. Subject with a history of alcohol or substance abuse that, in the opinion of the investigator, may be of clinical significance. 21. Subject who has undergone major surgery within 12 weeks of Visit 1 or has planned to undergo a major surgery before the end of the study. 22. Subject with diagnosis of asthma. 23. Inability to correctly use the sham device.