Vitamin D Supplementation and Respiratory Index of Severity in Children (RISC) in Pneumonia

Hormozgan University of Medical Sciences100 enrolled

Overview

Childhood deaths from pneumonia is almost 2000 times higher in developing countries than in developed countries. In 1970, pneumonia was responsible for 9% of all deaths in children under 5 years. This rate was 2% in 2007. Some studies have shown that supplementing with vitamin D reduces disease of the respiratory tract infection. Some other studies have shown anti-inflammatory effect of vitamin D in cell lines. Studies about the role of vitamin D supplementation in pneumonia in children are inadequate to conclude about its role. The aim of this study is to determine the efficacy of vitamin D supplementation in Respiratory Index of Severity in Children (RISC) hospitalized clinical outcomes of hospitalized patients with community-acquired pneumonia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Pneumonia

Interventions

Eligibility

Sex: ALLMin age: 2 MonthsMax age: 6 Years

Medical Language ↔ Plain English

Inclusion criteria * Aged between 2 months to 6 years * Definite diagnosis of pneumonia Exclusion criteria * Immunocompromised patients * Airway hypersensitivity or asthma * allergies * nasal polyps * Using inhaled medications to one month prior to the study * Receiving high doses of vitamin D * Avoiding to complete informed consent form

Outcomes

Primary Outcomes

Respiratory Index of Severity in Children (RISC)

For determining severity of pneumonia, RISC (Respiratory Index of Severity in Children) scoring system was used, including oxygen saturation, chest retraction, wheezing and refusal to feed, and also contains standards growth (weight for age).

Time frame: through study completion, an average of 4 days

Secondary Outcomes

Duration of hospitalization

Duration of hospitalization of the patient