The purpose of this study is to evaluate the clinical efficacy of traditional Chinese medicine in the treatment of asthma, and to promote the application in community hospitals.
Asthma is a serious global health problem and has increasing prevalence in many countries.Although asthma symptoms can be controlled by drug treatment to a large extent, there is still inadequate.Traditional Chinese medicine has a long history of treating asthma, and has a good clinical curative effect.The purpose of this study is to evaluate the clinical efficacy of traditional Chinese medicine in the treatment of asthma, and to promote the application in community hospitals. This could constitute a significant advance in asthma management. In this study, the investigators recruited patients with asthma exacerbation and remission stage, and gave the corresponding western medicine background treatment and traditional Chinese medicine treatment program.Participants will undergo a physical examination, lung function, blood and sputum collection. Exacerbation group belongs to cold type of asthma patients will take Ke Chuan Liu Wei Mixture, wind phlegm type of asthma patients will take Chuan Xiong Ping Chuan Mixture and Xie Wu Capsule,and hot type of asthma patients will take Dan Ma Jia Tablet for 14 days treatment, while the 3 control groups were given 3 corresponding placebo treatment for a total of 14 days. Remission phase of Yang deficiency patients in treatment group will take Zhi Chuan Capsule and Bu Shen Na Qi Granule, and in control group received a placebo treatment for a total of 60 days. Study visits will occur for 7 days of exacerbation group and 1 year for remission group. Questionnaires to assess asthma control will be completed during study of asthma at exacerbation stage within 44 days and on remission period within 12 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
288
Experience formula of famous traditional Chinese professor Yingen Wu
Experience formula of famous traditional Chinese professor Changrong Shao
Experience formula of famous traditional Chinese professor Jianhua Hu
Fenglin Street Community Health Service Center
Shanghai, Shanghai Municipality, China
NOT_YET_RECRUITINGKangjian Street Community Health Service Center
Shanghai, Shanghai Municipality, China
NOT_YET_RECRUITINGTianping Street Community Health Service Center
Shanghai, Shanghai Municipality, China
Asthma control rate
Asthma control rate will be measured during study of asthma at exacerbation stage within 44 days and symptom-free months will be measured on remission period within 12 months
Time frame: up to 12 months
Lung function(FEV1, PVC, PEF)
Measured during study of asthma at exacerbation stage within 44 days and on remission period within 12 months
Time frame: up to 12 months
Measurement of the fractional concentration of exhaled nitric oxide
Measured during study of asthma at exacerbation stage within 44 days and on remission period within 12 months
Time frame: up to 12 months
Blood routine examination
Measured during study of asthma at exacerbation stage within 44 days and on remission period within 12 months
Time frame: up to 12 months
Cytokine levels of serum and induced sputum
Measured during study of asthma at exacerbation stage within 44 days and on remission period within 12 months
Time frame: up to 12 months
Liver function test
Measured Liver function
Time frame: up to 12 months
Kidney function test
Measured Kidney function
Time frame: up to 12 months
T cell classification
Measured T cell classification of PBMC
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Experience formula of famous traditional Chinese professor Xiaopu Xu
Experience formula of famous traditional Chinese professor Yingen Wu
Experience formula of famous traditional Chinese professor Changrong Shao
Low dose combination for treating prescription of Ke Chuan Liu Wei Mixture
Low dose combination for treating prescription of Chuan Xiong Ping Chuan Mixture
Low dose combination for treating prescription of Xie Wu Capsule
Low dose combination for treating prescription of Dan Ma Jia Tablet
Low dose combination for treating prescription of Zhi Chuan Capsule
Low dose combination for treating prescription of Bu Shen Na Qi Granule
Longhua Hospital Affiliated Shanghai University of TCM
Shanghai, Shanghai Municipality, China
RECRUITINGFengxian District Hospital of TCM
Shanghai, Shanghai Municipality, China
NOT_YET_RECRUITINGTime frame: up to 12 months
Cytokine levels of induced sputum
Measured cytokine levels of induced sputum supernatant
Time frame: up to 12 months