The purpose of this study is to investigate the effects of alpha-lipoic acid supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.
In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of both sexes will be supplemented with either 600 mg of alpha-lipoic acid (experimental condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before intervention, all participants will be informed about the study protocol, fill a medical history questionnaire and sign an informed consent form. Moreover, measurements of anthropometric characteristics and physiological parameters, as well as a VO2max test will be performed. Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
10
A trial of exercise before and after 4 weeks of alpha-lipoic acid supplementation.
A trial of exercise before and after 4 weeks of placebo administration.
Department of Physical Education & Sport Science of the University of Thessaly
Trikala, Karyes, Greece
Change in redox status after exercise
Indices of blood redox status
Time frame: Before, immediately after and 1 hour after each trial of exercise
Body composition
Body fat percentage
Time frame: Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo
Blood pressure
Blood pressure at rest
Time frame: Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo
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