Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer

Inclusion Criteria: * initial treatment of advanced nasopharyngeal carcinoma Ⅲ-Ⅳ patients with pathologically confirmed (according to 2010 UICC staging, T3-4, N0-3), without evidence of distant metastasis (M0). Have measurable tumor lesions. * KPS≥70 points. * the age of 18-70 years old, male or female. * no major organ dysfunction; normal bone marrow function (WBC ≥4.0 × 109 / L, platelets ≥100 × 109 / L, hemoglobin ≥90g / L), normal liver function (total bilirubin, alanine aminotransferase, aspartate aminotransferase ≤1.5 times the upper limit of normal), normal renal function (creatinine ≤ 1.5 times upper limit of normal). * understand this study and signed informed consent. Exclusion Criteria: * distant metastasis. * who had received prior chemotherapy. * patients have physical or mental illness, and by researchers believe that patients can not be completely or fully understood in this study possible complications. * pregnancy (via the urine or serum β-HCG test confirmed) or during lactation. * serious complications, such as uncontrolled hypertension, heart failure, diabetes and so on.