Efficacy of Idarubicin, Cytarabine and Cyclophosphamide (IAC) Regimen in Relapsed/Refractory AML

Inclusion Criteria: 1. Age of less than 60 years old; 2. Patients that meet the diagnostic criteria(WHO 2008 criteria) of AML (except APL subtypes). 3. Patients with a confirmed pathologic diagnosis of AML which had relapsed or refractory. 4. Patients with ECOG score of ≤ 2; 5. Adult patients are willing to participate in the study and sign the informed consent by themselves or by their immediate family. Patients under 18 years old willing to participate should have their legal guardians sign the informed consent. Exclusion Criteria: 1. Patients who had received reinduction therapy including cyclophosphamide are excluded. However, patients who had received regimens including cyclophosphamide before relapse are eligible. 2. Patients with other blood diseases(for example, haemophiliacs) are excluded. 3. Relapsed patients with only extramedullary leukemia; 4. After allogeneic hematopoietic stem cell transplantation; 5. With mutation of breakpoint cluster region-Abelson(BCR-ABL) fusion gene and in need of tyrosine kinase inhibitors therapy; 6. Acute panmyelosis with myelofibrosis and myeloid sarcoma patients; 7. Had other malignant tumor in need of treatment; 8. Had active cardiovascular disease; 9. Patients with other factors which were considered unsuitable to participate in the study by the investigators.